Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway.
نویسندگان
چکیده
Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20-like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf-mitogen-activated protein kinase signaling in cancer cells.
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عنوان ژورنال:
- Cancer research
دوره 65 13 شماره
صفحات -
تاریخ انتشار 2005